SCENARIOS will devise and demonstrate a comprehensive set of technological solutions to address the detection, (bio)monitoring, long-term toxicity, risk assessment, pollution control and remediation of Per- and polyFluoroAlkyl Substances (PFASs) as a test bed for zero pollution ambition from refractory and mobile organic chemicals. SCENARIOS's approach and technologies will be self-sustainable, (near) net-zero energy and will smoothly integrate in the circular economies of EU countries and worldwide. A harmonised composition of the project consortium encompassing renewed academic and research centers and competitive technological SMEs will ensure SCENARIOS? replication and impact and continental level and beyond. The project will fill the knowledge gap and deliver disruptive remediation TRL advancements for probably the most awkward and widespread toxic class of contaminants -PFAS- with unprecedented energetic balance and the near absence of external chemical additions promoting EU leadership in the sector and a significant advance in the research field. The industrial core of SCENARIOS will enable four demonstrations (case studies) within EU industries and a public health institution stepping forward a set of industrial and societal sectors where pollutant remediation and health surveillance have excellent potential for the Green Deal implementation.