The CHERRIES consortium, consisting of 12 renowned and EU-FP experienced universities, research organisations, SMEs, CSOs, healthcare organisations incl. a private hospital, business and innovation centres and regional authorities from seven European countries. The CHERRIES model will support healthcare research and innovation policy and pilot actions by interlinking RRI, demand-side policy and territorial innovation models incl. smart specialisation. This pilot innovation process will be implemented and tested in the territories of Murcia (ES), Örebro (SW) and the Republic of Cyprus (CY). Subsequently, three additional Mirror territories will be supported in adopting the CHERRIES model. The model applies RRI methods in the innovation process, not only contributing to more innovative territorial environments but also to more suitable single innovations that therefore have a higher chance of being widely adopted and establish them successfully on the market. With this innovative design processes, the project contributes to more open, transparent and democratic R&I systems in the engaged territories and beyond, creating societal, democratic, environmental, economic and scientific impacts as well as tackling transformation processes of the organisations involved.