Further efforts to achieve greater efficiency in allocating healthcare resources are needed in order to guarantee the sustainability of public health systems. The exponential production of new evidence is a challenge in achieving this goal. Newly validated innovative technological tools for systematic evidence identification, evaluation, and synthesis may allow for a more efficient production of evidence to inform healthcare decisions. However, it is essential to build capacity among health care professionals to properly use these tools as well as formulate collaborative strategies to implement them. This research proposal aims to evaluate a strategy for capacity building to produce "Living Evidence" syntheses to generate integrative evidence-based products that support decision-making. Consists of three complementary projects aimed at: [WP1] producing Living Overviews of previously selected priority topics in the area of cancer and respiratory diseases integrated into the Epistemonikos-L.OVE project, an innovative initiative and platform in progress that allows to generate systematic evidence synthesis in a rigorous and efficient way, displaying it in a friendly format; [WP2] preparing and disseminating Friendly Summaries of Evidence for highly relevant questions from the prioritized health topics to inform clinicians and decision makers, following validated methods; and [WP3] updating evidence supporting recommendations in clinical practice guidelines (Living Guidelines) related with the same topics, through the development of living overviews in collaboration with two European guideline developers, and following the GRADE approach to rate the quality of evidence and generate summary of findings tables. In addition to the delivery of training, the project proposes a collaborative work strategy with different actors in the health system to carry out these actions. Information will be collected throughout the whole process to assess the efficiency of this strategy.