NEFERTITI is a unique project that establishes 10 interactive thematic networks and bring together 45 regional clusters (hubs) of demo-farmers and the involved actors (advisors, NGOs, industry, education, researchers and policy makers) in 17 countries. NEFERTITI focuses on creating added value from the exchange of knowledge, actors, farmers and technical content over the networks in order to boost innovation uptake, to improve peer to peer learning and network connectivity between farms actors across Europe, thus contributing to a more competitive, sustainable and climate-smart agriculture. NEFERTITI address 10 themes that have been chosen based on key concerns of the farming communities of the regional hubs in the project, covering together a balanced range of themes over three main agricultural sectors: animal production, arable farming and horticultural production. The themes have also been chosen regarding their innovation potential, their demonstration potential and the cross-fertilisation potential among the themes, the sectors and the actors. Themes are closely linked to the H2020 Thematic Networks and will connect with other organisational structures at grass root level, like EIP operational groups and study clubs that will confer to the project a key role of accelerator and empowerment of the dissemination and of the uptake of the practical-oriented knowledge delivered by all EIP related projects. A monitoring and learning program supports the systematic extraction of lessons learnt, lessons to be shared with wide audiences including AKIS actors and public authorities. A web based platform unlocks the experience, actors, demo details and the related content for wide spread sharing, enhanced by dedicated production of relevant material (including high-quality professional videos) in each language of the partners. NEFERTITI will engage a policy dialogue with EU Regions to match farmers and policy makers’ interests in view of the networks sustainability.