The European commissions’ Entrepreneurship 2020 action plan focuses on “reigniting the culture of entrepreneurship in Europe and nurturing the new generation of entrepreneurs”, as an area of an immediate intervention. “Smart Specialization” is the collective process that more than 170 European regions and 16 countries are now using to identify their strengths and their opportunities (http://s3platform.jrc.ec.europa.eu/s3-platform-registered-regions). It is based on a strong partnership between business, public sector and knowledge institutions to jointly design and implements their research and innovation investment strategies. In fact, the vision of Crete's development plan under the NSRF 2014-2020 is a “dynamic and sustainable Crete”. Dynamic in the sense of having an integrated strategy to exit the economic crisis by investing and strengthening the interconnection and export orientation of the agri-food sector, which is one of the four dynamic sectors identified in the context of the smart specialization of the regional economy of Crete. The same vision is registered in “smart Specialisation” plan of DTRaIN partners regions, identifying the agri-food industry as a dynamic sector for entrepreneurship and local development. Professionals working in the agri-food sector lack the skills for the fortification of local products brand names, and to face the challenge of the constantly changing and highly competitive economic environment. The Design Thinking methodology has been used to revolutionize entire industries and establish an enviable competitive advantage for their companies. Focused on listening, user empathy, whole-brain thinking, collaboration, and experimentation, Design Thinking can be applied in any field and product development to business planning and beyond. Best of all, it is believed that it is teachable to managers and scalable throughout a company.Based on the above, the DTRaIN Project objective is to revitalize the production in the agri-food sector of partners regions, by promoting the acquisition of high-quality skills for managing staff and entrepreneurs working in the sector. To address this objective, a European “Design Thinking” professional profile will be developed, based on a qualification scheme for validating learning outcomes, according to ECVET recommendations, and in line with ISO 17024 norm. More specifically, the aims of the DTRaIN Project are: Design a VET Curriculum and develop training content (EQF 4-5) for professionals in the agri-food sector, willing to upgrade their skills in Design Thinking for innovation methodology.  Design an innovative educational model based on a learner-centered approach, in a flipped classroom ubiquitous environment. Develop training material based on the Educational Model  Produce a Qualification scheme development.Direct target group and users of the training material will be professionals managing staff in agri-food companies that act as work-based trainers in their companies as well as educators in initial and continuous Vocational Training Institutes (EQF level 4&5).The Project implementation has been articulated in sequential activities grouped in seven work packages to achieve the fixed goals, carried out in close cooperation by all the institutions involved. The expected impact of the project is:-the improvement of the occupational qualification and professional skills of professionals working in the agri-food sector, in establishing a strong brand name in markets. -the updating of the professional profile of learners being certified under “DTRaIN qualification scheme” as Design thinking, allowing easier mobility across companies and countries. -Vet institutes to enrich their training services and pieces of training including an “innovative educational model” for implementing a VET curriculum delivering training content (EQF 4-5) for professionals in the agri-food sector, that can lead to a certification.