Climate projections for the Middle East and North African (MENA) region indicate warmer and drier conditions with increased frequency of natural disasters. Agriculture is one of the most vulnerable economic sectors to climate change, mainly due to the limited availability of water and land resources in the two target MENA countries (Egypt and Jordan). There is future risk of higher skills shortages in ‘niche’ areas related to the impact of climate change to agricultural sectors and food production. In particular, there is need for highly specialised scientists in the field of agriculture and food security who want to combine scientific and social or policy skills to better understand and make significant contributions to climate adaptation and mitigation in agriculture and food security. It is critical to integrate agricultural science with related subjects that impact on sustainability and food security such as geo-politics, legislation and regulation, consumer pressures, economics, agro-ecology and environmental stewardship, especially at the post-graduate level. An inter/multidisciplinary MSc programme in Climate Change, Agricultural Development and Food Security (CCSAFS) is urgently needed. CCSAFS is driven by the Bologna process and a multi-stakeholder approach advanced through a participatory or negotiated curriculum, innovative methodologies such as the 10Cs transversal skills in a problem-based learning environment enabled by ICTs, blended learning, SDGs and agro-food entrepreneurship in teaching, learning and outreach activities. Graduates will be equipped with interdisciplinary knowledge and agro-food entrepreneurship and ethics to promote sustainable agricultural production, food security and climate change adaptation. CCSAFS will help to overcome the threats to agriculture and food security in a changing climate, exploring new ways of helping vulnerable rural communities to compact hunger and adjust to local, regional and global changes in climate.