10.2 Summary in English for general dissemination purposes The Health and Technology Research Center (H&TRC) is embedded in Escola Superior de Tecnologia da Saúde de Lisboa (ESTeSL) building creating a mutual benefit in the use of facilities, equipment, and human resources. The aim and the strategy of H&TRC for 2018-2022, is in line with the aims of the research center, in line with the ongoing projects and in the multidisciplinary knowledge of the research team. H&TRC is organized in 4 areas of research. Genetics and metabolism; Environmental Health; Gerontology and Geriatric Health; Radiation and Health. Nevertheless, they have a single common denominator: the study of health technologies, health, and well-being. The primary question of the H&TRC is the study of the determinants of human health, disease and well-being and the study of different factors (Environmental, nutritional, exercise and genetic) that can affect them. Moreover, the aim is to develop health technologies that can improve diagnostic techniques or therapeutic technics. The center involves 22 Ph.D. researchers (19 full-time professors). The center also includes 3 Ph.D. students, several Master students (about 30) and 19 collaborators. The research team is characterized by multidisciplinarity, with expertise in molecular genetics, biostatistics, chemistry, nutrition, cardiorespiratory, sociology, microbiology, molecular biology, clinical biochemistry, toxicology, hematology physiotherapy, pharmacy, environmental health, endocrinology, orthoptics, radiation, medical imaging. The scientific quality of the team is demonstrated by an outstanding portfolio of publications in international journals and participation in collaborative projects. Moreover, the research center collaborates with international networks and institutions. Researchers are involved in 9 undergraduate courses and in 5 Master courses, all in the Health and Technology field. All the research projects are managed in the laboratories of H&TRC - human genetics, biochemistry, dietetics and nutrition, physiotherapy, health and environment, vision sciences, Microbiology, Pharmacy, Clinical physiology, Vision Sciences, hematology, and radiation. These laboratories are well equipped to carry out the proposed strategic plan. The center will promote scientific dissemination by the organization of national and international meetings and workshops. Also, the H&TRC strategy for 2018-2022 is to promote education courses about cutting-edge technologies employed in our research and search for new international partners and strengthen the relationships with the existing ones Due to interdisciplinary approaches and methodologies H&TRC is highly competitive thanks to: i) the multidisciplinary background of its members; ii) laboratory conditions, well equipped and train team; iii) the undergraduate and postgraduate courses that attract new researchers, and principally young investigators; and iv) internationalization, that permits the exchanging of resources, of knowledge and technology. 10.3 Summary in English for evaluation The H&TRC is embedded in IPL, in the ESTeSL building creating a mutual benefit in the use of facilities, equipment, and human resources. The aim and the strategy of H&TRC for 2018-2022, is aligned with the aims of the research center, with the ongoing projects, the ongoing proposals for new projects and in the multidisciplinary knowledge of the research team. Moreover, H&TRC is committed to aligning with societal challenges from European Commission established in the H2020 work program. Taking into account the different areas of its researchers (multidisciplinary) H&TRC is well positioned to promote multidisciplinary projects in health technologies. The majority of the researchers are full-time professors at ESTeSL. Moreover, the H&TRC includes students in all the research projects which is a strength of the center. Researchers are involved in 9 undergraduate courses and in 5 Master courses, all in the Health and Technology field. The center involves 22 Ph.D. researchers, 19 full-time professors, 2 invited professors that work in Hospitals, and one invited professor from a private University. The Research center will be implemented by these 22 highly competitive senior investigators, including also 3 Ph.D. students, several Master students (about 30) and 19 collaborators. The research team is characterized by multidisciplinarity, with expertise in molecular genetics, biostatistics, chemistry, dietetics and nutrition, cardiorespiratory, sociology, microbiology, molecular biology, clinical biochemistry, toxicology, hematology physiotherapy, pharmacy, environmental health, endocrinology, orthoptics, radiation, medical imaging. The scientific quality of the team is demonstrated by an outstanding portfolio of publications in international journals and participation in collaborative projects. Moreover, the research center collaborates with international networks and institutions. To achieve the aims of H&TRC the center is organized in 4 research areas. Genetics and metabolism; Environmental Health; Gerontology and Geriatric Health; Radiation and Health. Nevertheless, they have a single common denominator: the study of health technologies, health, and well-being. The primary question of the H&TRC is the study of the determinants of human health, disease and well-being and the study of different factors (Environmental, nutritional, exercise and genetic) that can affect them. Moreover, the aim is to develop health technologies that can improve diagnostic techniques or therapeutic technics. The research areas in H&TRC has the following objectives for 2018-2022: i) research in genetics and metabolism in obesity, using cutting edge technologies – "Next Generation Sequencing" (NGS), research in Diabetes, research in in Hemoglobinopathies Sickle cell disease studying molecular diagnosis, genetic modulators of fetal hemoglobin, microbiome by NGS and the development of new therapeutic, research Biopsychology and psychoimmunology, research in toxins their metabolites and biomarkers of health and risk, research in Inflammatory Bowel Disease (IBD) and nutrition associated with microbiome study by NGS analysis, research in neurological physiotherapy, research in Gerontology and Geriatric Health, integrating multidisciplinary approaches, research in medical imaging and research in Health Technologies in biological and chemical contamination in different settings, contributing to improve the quality of the health service, public, occupational and environmental health. All these areas (projects) are managed in the laboratories of H&TRC: Laboratory of human genetics, Laboratory of Biochemistry, Laboratory of dietetics and nutrition, Laboratory of physiotherapy, laboratory of health and environment vision sciences laboratory, Microbiology Laboratory, Pharmacy Laboratory, Laboratory of Clinical Physiology, Laboratory of Vision Sciences, laboratory of hematology and radiation laboratory. These laboratories are well equipped to carry out the proposed strategic plan although some improvements are needed. The existence of graduate and postgraduate students in the ESTeSL that interact with the H&TRC (internships and thesis), is one distinctive characteristic that keeps the center highly competitive. The aim of the center is to increase the number of masters and doctoral students involved in study designs implemented by the unit. Is also the intention to promote short duration practical courses, keeping an old tradition of the ESTeSL and of researchers from H&TRC. The center will promote scientific dissemination by the organization of national and international meetings and workshops aiming at mutual benefit between entities and participation in common projects. Also, one strategy for 2018-2022 is to promote education courses about cutting-edge technologies employed in our research. The center will look for new international partners and strengthen the relationships with the existing ones. For this propose is our intention to present join projects for funding agencies, and to organize international meetings, in Portugal or abroad. H&TRC is headed by a Unit Coordinator who, along with coordinator commission of 4 researchers, is responsible for the organization of the unit. The coordinator commission is supported by a Research Office which links with the national support structures. The scientific committee of H&TRC meets two times per year, to approve the action plan and progress reports. Due to interdisciplinary approaches and methodologies H&TRC is highly competitive thanks to: i) the multidisciplinary background of its members; ii) laboratory conditions, well equipped and train team; iii) the undergraduate and postgraduate courses that attract new researchers mainly young investigators; and iv) internationalization, that permits the exchanging of resources, knowledge and technology, scientific publications in electronic format. O Centro de Investigação em Saúde e Tecnologia (H&TRC) está instalado na Escola Superior de Tecnologia da Saúde de Lisboa, criando um benefício mútuo na utilização de instalações, equipamentos e recursos humanos. O objectivo e a estratégia do H&TRC para 2018-2022, estão em consonância com os objectivos do centro de investigação, em consonância com os projectos em curso e com o conhecimento multidisciplinar da equipa de investigação. O H&TRC está organizado em 4 áreas de investigação: genética e metabolismo; ambiente e saúde; gerontologia e saúde geriátrica; radiação e saúde. No entanto, têm um único denominador comum: o estudo das tecnologias da saúde e a saúde e o bem-estar. A principal questão de investigação do H&TRC é o estudo dos determinantes da saúde humana, da doença e do bem-estar e o estudo dos diferentes fatores (ambientais, nutricionais, físicos e genéticos) que podem alterá-los. Além disso, o objetivo do centro é desenvolver melhores tecnologias de saúde bem como técnicas de diagnóstico ou terapêuticas. O centro envolve 22 investigadores doutorados (19 professores em tempo integral). O centro também inclui 3 estudantes de doutoramento, vários alunos de mestrado (cerca de 30) e 19 investigadores colaboradores. A equipa de investigação é caracterizada pela multidisciplinaridade, com expertise em genética, bioestatística, química, dietética e nutrição, cardiopneumologia, Sociologia, Microbiologia, Biologia molecular, Bioquímica clinica, Toxicologia, Hematologia fisioterapia, farmácia, saúde ambiental, endocrinologia, ortóptica, radiação, imagens médicas. A qualidade científica da equipa é demonstrada por uma excelente carteira de publicações em periódicos internacionais e participação em projetos colaborativos. Além disso, o centro colabora com redes e instituições internacionais. Os investigadores estão envolvidos em 9 cursos de 1º ciclo e 5 de mestrado, todos no campo da tecnologia da saúde. Todos os projetos são geridos nos laboratórios do H&TRC-lab genética humana, lab bioquímica, lab dietética e nutrição, lab fisioterapia, lab ambiente e saúde, lab microbiologia, lab farmácia, lab fisiologia clinica, lab ciências da visão, lab hematologia e lab radiação. Estes laboratórios estão bem equipados para realizar o plano estratégico proposto. O centro irá promover a disseminação científica com a organização de reuniões e workshops nacionais e internacionais. A estratégia do H&TRC para 2018-2022 envolve promover cursos sobre tecnologias de ponta utilizadas nos projectos a decorrer e procura de novos parceiros internacionais, fortalecendo as relações com as existentes Devido à sua abordagens multidisciplinar o H&TRC é altamente competitivo, graças a: i) base multidisciplinar de seus membros; II) condições de laboratório, bem equipados; III) cursos de graduação e pós-graduação que atraem novos investigadores e principalmente jovens investigadores; e IV) internacionalização, que permite a troca de recursos, de conhecimento e tecnologia.