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image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
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Consecuencias de la acción del calcio intracelular en la activación de la proteína Kinasa A y las consecuencias a nivel conductual de su manipulación

Authors: Zelaya Romero, Jefreey;

Consecuencias de la acción del calcio intracelular en la activación de la proteína Kinasa A y las consecuencias a nivel conductual de su manipulación

Abstract

Treball final de Grau en Psicologia. Codi: PS1048. Curs acadèmic 2015-2016 El estresante estilo de vida de la sociedad actual junto con la mala concepción sobre las posibles consecuencias del consumo de alcohol podrían ser algunas de las causas de que actualmente el alcohol sea una de las drogas más consumidas a nivel mundial según la OMS. Sin embargo, a pesar de todos los avances de la neurociencia, el mecanismo exacto de cómo actúa el alcohol en el SNC nos es aún desconocido. El objetivo de este trabajo es tratar de plantear y dar pruebas a favor de una hipótesis sobre como podría actuar realmente el alcohol en el cerebro. El método de este trabajo consta del análisis de 4 estudios que muestran las manipulaciones de diferentes mediadores de calcio y AMPc-­‐PKA y las consecuencias de esas manipulaciones a nivel molecular, celular, neurobiológico y conductual. Por una parte los resultados obtenidos nos muestran que posiblemente, estos mediadores de calcio tengan una función muy importantes a la hora de explicar el mecanismo de acción del alcohol en el cerebro. Pero, no obstante, no son suficientes evidencias como para afirmar con completa claridad y certeza que este sea el mecanismo exacto de actuación del alcohol en el SNC. The stressfull way of life of our nowadays society in adition to the missconception of the potencial consequences from alcohol consum could be some of the reasons for why alcohol is the worldwide most consumed drug according to OMS. However, besides all the neuroscience developments, the true mechanism of alcohol functionament on the SNC has been not proved. The method of this paper consists of the analysis of 4 studies that show the manipulations of the different mediators of calcium and cAMP-­‐PKA and the consequences of these manipulations at a molecular, cellular, neurobiological and behavioural level. The results, in one hand, show that is possible that those mediators of calcium are important for understands the true mechanism of how alcohol works in the brain. However, there are no enough evidences to completely agree that this is the exact mechanism by which alcohol acts at a central level.

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Spain
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Keywords

Locomotor activity, Ethanol, Etanol, Conducta de ingesta, Ethanol intake, Calcio, NMDA, Grau en Psicologia, Bachelor's Degree in Psychology, AMPc, PKA, Calcium, Grado en Psicología, SNC, CNS, Reflejo de enderezamiento, Righting reflex

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citations
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
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