2nd generation biofuels gained more importance in recent years since they enable greenhouse gas emission reductions in the transport sector on a larger scale. One promising way to produce alternative fuels is the Biomass-to-Liquid (BtL) process with the Fischer-Tropsch synthesis which produces synthetic hydrocarbons that could directly be used as liquid fuels in an existing infrastructure. One major issue of this process is the production cost. Within the European COMSYN project (Compact Gasification and Synthesis process for Transport Fuels), a new BtL process concept is developed that aims to reduce biofuel production cost up to 35 % compared to alternative routes.