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Measurement of Barrier Tissue Integrity with an Organic Electrochemical Transistor

descriptionPublicationkeyboard_double_arrow_right Article , Journal 05 Sep 2012 France Publisher:WileyJournal:Advanced Materials, volume 24, pages 5,919-5,923 (issn: 0935-9648, eissn: 1521-4095,

Authors: Jimison, Leslie H.; Tria, Scherrine A.; Khodagholy, Dion; Gurfinkel, Moshe; Lanzarini, Erica; Hama, Adel; Malliaras, George; +1 Authors

doi: 10.1002/adma.201202612

pmid: 22949380

Measurement of Barrier Tissue Integrity with an Organic Electrochemical Transistor

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Abstract

The integration of an organic electrochemical transistor with human barrier tissue cells provides a novel method for assessing toxicology of compounds in vitro. Minute variations in paracellular ionic flux induced by toxic compounds are measured in real time, with unprecedented temporal resolution and extreme sensitivity.

Country

France

Related Organizations

Polytechnic University of Milan
Italy
École Normale Supérieure
France
Laboratory of Computing, Modelling and Optimization of the Systems
France
Mines Saint-Etienne
France
Center for Nano Science and Technology
Italy

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Keywords

330, Ethanol, Transistors, Electronic, Cell Survival, Biosensing Techniques, Equipment Design, Hydrogen Peroxide, Equipment Failure Analysis, Humans, Biological Assay, [SPI.NANO]Engineering Sciences [physics]/Micro and nanotechnologies/Microelectronics, Caco-2 Cells, Organic Chemicals, [SPI.NANO] Engineering Sciences/Micro and nanotechnologies/Microelectronics

Impact byBIP!

	citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	154
	popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.	Top 1%
	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Top 10%
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Top 1%