ABSTRACTThe study explored the efficacy of Salvia chudaei ethanolic extract in managing hyperlipidemia, hyperglycemia, and oxidative stress induced by Triton X‐100 in Wistar rats. Twenty‐four rats were divided into four groups: Control, S. chudaei‐treated, Triton‐induced hyperlipidemic, and a combination of Triton + S. chudaei treatment. Triton X‐100 raised serum levels of total cholesterol, triacylglycerol, and low‐density lipoprotein (LDL) while lowering high‐density lipoprotein (HDL) cholesterol, leading to oxidative stress marked by increased malondialdehyde (MDA) and reduced antioxidant activity in liver and kidney tissues. Administration of S. chudaei extract effectively reversed these adverse effects, significantly lowering cholesterol, triacylglycerol, and LDL levels, and improving HDL cholesterol. It also enhanced antioxidant defenses and reduced oxidative stress markers, demonstrating its protective role against metabolic dysfunction. High‐performance liquid chromatography analysis confirmed the presence of bioactive compounds in the extract that contribute to these benefits. The findings suggest that S. chudaei ethanolic extract possesses strong antihyperlipidemic, antihyperglycemic, and antioxidant properties, making it a promising natural agent for preventing and treating hyperlipidemia and oxidative stress. This positions S. chudaei as a potential new therapeutic approach in the management of metabolic disorders.