AbstractTwenty first century faces unprecedented challenges for the management of global waterways. The Himalayan waterways in Asia are exposed to unpredictable climatic warming together with anthropogenic perturbations caused by population growth, land use change and socio‐economic development. Given the increased public concerns on the Himalayan Mountain development programmes including the hydropower and tourism, there has been a growing need of the use of interdisciplinary scientific approaches to address water resources challenges that the Himalayan region has faced during the 21st century. Ecohydrology is an emerging scientific tool that explores key hydrological processes regulating structure and function of ecosystems, as well as assessing the impact of biological processes on water cycle variables under rapidly changing environment. The International Geosphere‐Biosphere Programme and the International Hydrological Programme hosted by the United Nations Educational, Scientific and Cultural Organization have adopted ecohydrology as a sustainable development tool by linking water resources and poverty eradication and ecosystem restoration, irrigation, energy and sanitation. However, ecohydrology tool needs to be reconfigured for sustainable development of rapidly changing Himalayan waterways. Here we propose the advancement of ecohydrology by developing various integrated frameworks of ecology, hydrology, hydraulics and sociology for resilient waterways in the Asian Himalayas.