Due to its geographical condition and geophysical location Bangladesh is one of the world’s most vulnerable country, which will become more vulnerable to the impact of climate change. According to the Global Climate Risk Index 2020 and Intergovernmental Panel on Climate Change (IPCC) 2011, Bangladesh is the seventh most climate change-affected nation in the world. This chapter elaborates on the possible impacts of climate change in Bangladesh through various natural disasters, i.e., increasing temperature, sea level rise, salinity intrusion, cyclone, storm surges, drought, etc. and also discusses the comprehensive disaster management approach in Bangladesh. It is now a worry in the scientific community that climate change could dramatically change weather patterns like the disease spread of epidemics (such as COVID-19) from vulnerable regions to invulnerable regions. All sectors will be affected by the impact of climate change, not only Bangladesh but also other South Asian countries. In Bangladesh, both the government and nongovernmental organizations (NGOs) are trying to prevent and alter the impacts of climate change by enhancing several adaptation and mitigation approaches. But still, coastal districts and northern areas in Bangladesh are facing many climatic issues, such as flash floods, super cyclones, salinity intrusion, storm surges, drought and riverbank erosion etc. Moreover, the government is taking the immediate response of shifting people in a cyclone center at the moment of extreme natural events but most of the peoples of the coastal districts in Bangladesh are illiterate so that they very careless about the awareness. On the basis of current information, it is suggested that the government should make some policy in disaster management for a sustainable solution for coastal areas in Bangladesh.