Defects of Cortical Microcircuits Following Early Exposure to Alcohol
Defects of Cortical Microcircuits Following Early Exposure to Alcohol
The interplay between excitatory pyramidal neurons and GABAergic interneurons is the basic building block of neocortical microcircuits and plays a critical role in carrying out higher cognitive functions. Cortical circuits are deeply and permanently disrupted by exposure to alcohol during brain development, the main non-genetic cause of intellectual disability. Here, I review experimental studies of fetal alcohol spectrum disorders, dealing with permanent cellular and molecular alterations of neocortical neurons and their connections.
- University of Turin Italy
Cerebral Cortex, Ethanol, Pyramidal Cells, Canonical circuit; Dendrites; Disinhibition; Fetal alcohol; Intellectual disability; Interneurons; Neocortex; Pyramidal neurons, Neocortex, Fetal Alcohol Spectrum Disorders, Pregnancy, Interneurons, Prenatal Exposure Delayed Effects, Humans, Animals, Female, GABAergic Neurons, Nerve Net
Cerebral Cortex, Ethanol, Pyramidal Cells, Canonical circuit; Dendrites; Disinhibition; Fetal alcohol; Intellectual disability; Interneurons; Neocortex; Pyramidal neurons, Neocortex, Fetal Alcohol Spectrum Disorders, Pregnancy, Interneurons, Prenatal Exposure Delayed Effects, Humans, Animals, Female, GABAergic Neurons, Nerve Net