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The interaction between ethanol and manganese in rat brain

descriptionPublicationkeyboard_double_arrow_right Article , Journal 01 Jan 1979Publisher:Springer Science and Business Media LLCJournal:Archives of Toxicology, volume 41, pages 307-316 (issn: 0340-5761, eissn: 1432-0738,

Authors: R. S. Srivastava; S. Singh; Girja S. Shukla; Satya V. Chandra;

doi: 10.1007/bf00296901

pmid: 435081

The interaction between ethanol and manganese in rat brain

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Abstract

The effect of combined administration of ethanol and manganese on the brain tissue of rats was investigated to evaluate the role of alcohol ingestion in inducing susceptibility to manganese poisoning. Ethanol and manganese alone and the combination of the two were administered orally daily to the rats for 30 days. Almost identical increase in the brain contents of manganese in rats receiving the metal alone and in combination with ethanol indicates that ethanol administration does not influence the accumulation of manganese in that organ. The copper contents of brain also increased to almost the same extent in these two groups. Synergistic effect of ethanol and manganese was noticed on increasing the activity of ATPase and RNase while marked antagonistic effect was observed on the activity of MAO. The mechanism and the significance of these neurochemical alterations occurring after the administration of ethanol and manganese have been discussed.

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Keywords

Male, Manganese, Ethanol, Manganese Poisoning, Brain, Mitochondria, Rats, Succinate Dehydrogenase, Zinc, Animals, Drug Interactions, Lysosomes, Copper

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