There are papers on association about natural resources, economic expansion, and their effect on the quality of the environment in Central Asia. However, no study has investigated the effect of human capital in this nexus concerning the Central Asian states. Thus this study investigates the link between natural resources, economic expansion, human capital, and CO2 in Central Asian states by employing Pooled Mean Group (PMG) and the Dumitrescu and Hurlin (DH) causality tests from 1995 to 2018. The outcomes from the PMG model showed that human capital has an opposite and significant association with CO2 in the short and long run. Therefore, it is stated that local human capital with higher environmental awareness through education and training makes a positive impact on environmental quality. With the growth of the natural resources index and expansion of the economy, Central Asian emissions will rise. With a positive and substantial coefficient of the natural resources, the finding suggests that, even though Central Asian states have plenty of natural resources, they are unable to exploit them efficiently to reap good rent advantages to reduce the emissions. The outcomes of the causality test stated that the index of natural resources, economic expansion, and human capital have one-way causality with emissions. The important policies and recommendations for maintaining the economic and environmental sustainability of this country are provided at the end of this paper.