There is an increasing demand of hydrocarbons owing to the fluctuations in crude oil prices and reduced fossil resources. Lignocellulosic biomass is seen as a potential renewable source of sustainable hydrocarbons. The hydropyrolysis of jatropha seed de-oiled cake has been carried out at various hydropyrolysis temperatures (300, 350, 400 and 450 °C) and pressures of hydrogen (1, 20, 40 and 52 bar). It has been observed that the liquid bio-oil yields have increased with pyrolysis temperature and pressure. It was also found that 40 bar is the optimum value of hydrogen pressure for the hydropyrolysis reactions at 450 °C to obtain maximum liquid yield (17 wt.%) in the given experimental setup. The frequency factor of 98 s−1 and activation energy of 29 kJ/mol are the lowest at 40 bar reaffirming the fact that heat and mass transfer limitations are the least at 40 bar pressure.