This study was built on the basis of an experimental study that was carried out on a simple refrigeration system that works with R134a as a refrigerant, and based on the real dimensions of the system and the experimental results, the Ansys fluent software was used to simulate the system to prepare the system to introduce the nanoparticles theoretically. Since the nanoparticles preparation process is expensive, this research presents a simple, easy, and inexpensive method for the preparation process based on the following materials, distilled water, ammonia, copper nitrate, and cerium nitrate to synthesize seven types of nanoparticles as a single oxide and as a mixture from two different oxides The results of preparing using X-Ray Diffraction and Scanning Electron Microscopy proved that particles of samples were spherical in shape, with suitable average diameter ranging between 78.95, 79.9, 44.15 and 63.3 nm for both copper oxide, cerium oxide, first mixture, and second mixture, respectively, the theoretical study confirmed that both copper oxide, cerium oxide, and the mixture consisting of both improved the performance of the refrigeration system and reduced energy consumption.