Recent results are summarized from HSST studies in three major areas that relate to assessing nuclear reactor pressure vessel integrity under pressurized-thermal-shock (PTS) conditions. These areas are irradiation effects on the fracture properties of stainless steel cladding, crack run-arrest behavior under non-isothermal conditions, and fracture behavior of a thick-wall vessel under combined thermal and pressure loadings. Since a layer of tough stainless steel weld overlay cladding on the interior of a pressure vessel could assist in limiting surface crack extension under PTS conditions, its resistance to radiation embrittlement was examined. A stainless steel overlay cladding, applied by a submerged arc, single-wire, oscillating-electrode method, was irradiated to 2 × 1023 neutrons/m2 (> 1 MeV) at 288°C. Yield strength increases up to 27% and a slight increase in ductility were observed. Charpy V-Notch data showed a ductile-to-brittle transition behavior caused by temperature-dependent failure of the 8-ferrite phase. The type 308 cladding, microstructurally typical of that in reactor pressure vessels, showed very little degradation in either upper-shelf energy or transition temperature due to irradiation. Crack-arrest behavior of A533 grade B class 1 steel was examined for temperatures extending above the onset of Charpy upper-shelf. Crack-arrest experiments that use wide-plate specimens have shown crack arrest occurring prior to transition to tearing or tensile instability. High values of crack-arrest toughness have been recorded (static values above 400 MPa m that are well above the maximum value that safety assessment criteria assume such materials can exhibit. A validation experiment was performed by exposing an intentionally flawed HSST intermediate test vessel to combined pressure and thermal transients. The experiment addressed warm-prestressing phenomena, crack propagation from brittle to ductile regions, and crack stabilization in ductile regions. Test and analysis results are summarized.