Flow around a solid sphere finds utility in numerous single- and two-phase engineering applications, such as sport balls, combustion systems, silt conveyance in waterways, hydraulic conveying, pneumatic equipment, food and chemical manufacturing. Therefore, this paper aims to examine the Casson nanofluids flow and heat transfer over a solid sphere that is saturated in an isotropic porous material in the presence of Stefan blowing and slip conditions. The forced situation is due to the presence of a stagnation point while the surface of the sphere is subjected to thermal slip conditions. Besides, various significant impacts are taken into account such as Lorentz force, thermal radiation, heat source/sink, and activation energy. The solution technique is based on non-similar transformations and implicit finite difference method with the Blottner algorithm. It is remarkable that, for all values of the activation parameter, the growth of Stefan number reduces the gradients of the velocity, temperature, and nanoparticle concentration. Also, the presence of the thermal slip factor reduces the temperature distributions. Additionaly, an increase in either the Casson parameter or Darcy number enhances the flow while both temperature and concentration are diminishing. Furthermore, there is an improvement in values of the Nusselt number up to 50.57 % when the magnetic parameter is varied from 0 to 6.