Abstract With the plan to increase nuclear generating capacity to 58 GWe and more than 30GWe under construction by 2020, China would have to confront the challenge from the transportation safety of nuclear material. In this paper, based on the analysis of transportation systems and the accident scenarios, the safety evaluation index system of spent fuel road transportation was established by using analytic hierarchy process (AHP), and the transportation safety evaluation model was constructed by weighted nearest neighbor method. By using the model, the safety evaluation of spent fuel road transportation in DaYa Bay nuclear power plant was carried out. The evaluation results showed that the whole transportation was safe, though it has safety risk caused by the weather and the junctions of the bridges and tunnels. In addition, the results from the fuzzy comprehensive evaluation method and the weighted nearest neighbor method are compared, which indicated that the weighted nearest neighbor method supplied a better decision support during the spent fuel road transportation.