Abstract A cascaded adsorption cooling system with an integrated evaporator/condenser can produce low temperature cooling, using waste heat sources. The choice of the working pair in such a system affects the system’s performance when driven by low temperature waste heat sources, which can be as low as 70 °C. This paper investigates the performance of various adsorbent/refrigerant working pairs in a cascaded adsorption system with an integrated evaporator/condenser using Simulink/MATLAB software. The cascaded system consists of two pairs of adsorber beds, a condenser, an evaporator and an integrated condenser/evaporator heat exchanger, forming upper and bottoming cycles. Five combinations of working pairs were investigated: ATO/ethanol + Maxsorb/R507A; Maxsorb/R134a + Maxsorb/propane; ATO/Ethanol + Maxsorb/propane; ATO/ethanol + AC-35/methanol; and Maxsorb/R134a + Maxsorb/R507A. The latter combination was used for validation and as a reference combination for assessing the performance of the investigated working pairs in terms of COP and cooling capacity. The results showed that the Maxsorb/R134a + Maxsorb/propane combination gives a higher COP compared to the reference combination, with up to 30.0% and 30.1% for the COP and cooling capacity, respectively; while ATO/ethanol + AC-35/methanol produces a similar performance to the reference case but uses natural refrigerants with low global warming potential and low cost adsorbent materials.