Abstract The hybridization of Solid Oxide Fuel Cell (SOFC) and gas turbine technologies provides an increase in system efficiency and economic performance. The latter aspect is significantly affected by fuel cell degradation, due to several mechanisms. However, hybrid systems allow different control strategies to minimize degradation effects on system performance and their impact on economic feasibility. A real-time distributed model of a SOFC was used to simulate fuel cell degradation in the cases of a standalone stack and a hybrid configuration, in the latter of which the numerical model is normally coupled with the hybrid system hardware components of the National Energy Technology Laboratory (NETL) hyper facility. The results showed how in a hybrid system it is possible, with an appropriate strategy, to maintain constant voltage even if the cell is degrading, reducing degradation rate during time. At constant power demand, fuel cell life could be significantly extended using the operating strategies allowed by coupling with a turbine (an order of magnitude longer than a standalone fuel cell), maintaining high system efficiency despite fuel cell degradation.