Water Distribution Networks (WDNs) represent a noteworthy field for possible implementation of Small Hydropower (SHP), by replacing Pressure Reduction Valves (PRV) with turbomachines, in particular Pump as Turbines (PaTs), to control and regulate the pressure, while harvesting energy otherwise wasted. Different models were developed to predict the performance and select the positioning of the PaTs for the maximum energy recovery but most of them neglect practical aspect such as: power grid limitations and optimal harvesting strategy. In this framework, we intend to propose a new method to select a PaT, defining its optimal working point, by introducing an energy exploitation coefficient. The proposed methodology is based on the experimental results of a real PaT tested in the high capacity hydraulic laboratory at Polytechnic University of Bari. Firstly, the selected commercial centrifugal pump was tested in both pump and turbine modes. Then, three different approaches, for the Best Efficiency Point (BEP) selection, are described and compared in terms of energy exploitation and capacity factor for a WDN. The first consists of selecting the BEP at the average flow rate, the second one considers the probability distribution of the flow rate and the corresponding available hydraulic energy, whereas the latter is based on the highest energy harvesting. By applying energy production, economic and environmental analyses, the new proposed methodology, based on the third approach, shows a remarkable advantage in terms of exploited energy. Indeed a remarkable 60% energy recovery is achieved with 334 ton CO2/year avoided. Furthermore, the impact of the electrical motor on the maximum power generation (cut-off) is considered. Eventually, useful insights for the future PaT selection and installation are discussed.