With impressive thermal outcomes, the nanofluids present multidisciplinary applications in the cooling processes, thermal systems, extrusion processes, heat storage devices and many more. The aim of current research is to inspect thermal impact of Jeffrey fluid with tiny particles under the assumptions of variable thermal conductivity. The problem is supported with applications of chemical reaction, activation energy and magnetic force. For heat and mass transfer phenomenon, Cattaneo-Christov diffusion theories have been implemented. The formulated model is solved by using the homotopy analysis method (HAM) with excellent accuracy. The graphical analysis is performed with specified range of parameters like 0.2⩽H⩽0.8, 0.1⩽ϖ⩽1.7, 0.0⩽N⩽1.5, 0.0⩽Π⩽3.1, 0.3⩽γ⩽0.6, 0.6⩽Ψ⩽3.2, 0.5⩽Ω⩽2.0, 0.0⩽Σ⩽1.5, 0.2⩽Nt⩽1.7, 1.0⩽Pr⩽1.9, 0.5⩽Sc⩽1.4,0.3⩽β⩽1.5, 0.1⩽ε⩽1.0, 0.2⩽Nb⩽1.7. The assessment of flow parameters is graphically evaluated. It is observed that both velocity profiles periodically enhance for Deborah number while temperature, microorganisms and concentration distributions decelerate. The greater estimates of variable thermal conductivity and heat generation improve the temperature distribution while conflicting scenario ensures for thermic relaxation constant.