Abstract Data developed by the Consortium for Research on Renewable Industrial Materials were used to estimate savings of greenhouse gas emissions and energy consumption associated with use of wood-based building materials in residential construction in the United States. Results indicate that houses with wood-based wall systems require 15–16% less total energy for non-heating/cooling purposes than thermally comparable houses employing alternative steel- or concrete-based building systems. Results for non-renewable energy consumption are essentially the same as those for total energy, reflecting the fact that most of the displaced energy is in fossil fuels. Over a 100-year period, net greenhouse gas emissions associated with wood-based houses are 20–50% lower than emissions associated with thermally comparable houses employing steel- or concrete-based building systems. Assuming 1.5 million single-family housing starts per year, the difference between wood and non-wood building systems represents about 9.6 Mt of CO 2 equivalents per year. The corresponding energy benefit associated with wood-based building materials is approximately 132 PJ year −1 . These estimates represent about 22% of embodied energy and 27% of embodied greenhouse gas emissions in the residential sector of the US economy. The results of the analysis are very sensitive to assumptions and uncertainties regarding the fate of forestland that is taken out of wood production due to reduced demand for wood, the continued production of co-products where demand for wood products is reduced, and the rate at which carbon accumulates in forests.