Abstract This paper presents an investigation of the energy consumption due to domestic hot water (DHW) production in large buildings. We have studied three types of reference buildings: one office, one residence and a 3-star hotel located in Senegal. The DOE2.1E (the building energy program of the Department of Energy Version 2.1E) has been used. One of its main advantage is that it allows to take into account both energy end use categories and a great number of parameters of the building energy performance. Four climatic regions have been identified and their equivalent “standard” conditions are all defined. Those conditions are the same as the current design and operating conditions of each type of building. The DHW energy consumption is calculated and compared with the total energy generated by all end uses (lighting, cooling/ventilation, DHW, and other equipment). Before we carry out wide and systematic simulations of the three buildings energy performance, we pay special attention to check and validate the DHW part of the DOE2.1E model. There was an agreement between the recorded monthly DHW energy load on the one hand, and on the other the computed results. We end up finding results that could open new perspectives for building a strategic methodology to provide guidelines for DHW energy saving measures in large buildings in West Africa. Furthermore, it is expected that energy researchers concerned about energy and environmental efficiency would consider this study for promoting CO 2 emission reduction in relation with DHW production in large buildings.