Abstract To address the energy consumption problem in the building sector, this study sought to develop a prototype of the multi-function smart window as a combination of the photovoltaic (PV) blinds and the ventilation system by considering two perspectives: (i) design of the multi-function smart window; and (ii) operation strategy for the multi-function smart window. The main findings can be summarized as follows. First, a comprehensive performance analysis of the multi-function smart window according to the application location of the ventilation system and the PV cell types was conducted to determine the optimal configuration of the multi-function smart window. Second, the hardware prototype of the multi-function smart window was implemented considering the PV cell type, PV tracker type, ventilation type, and filter. Finally, this study developed a software prototype that can monitor and control the multi-function smart window in real time based on the NI LabVIEW software program. Through the application of a novel building envelope system developed based on this study, it is expected that zero-energy buildings can be realized and buildings’ indoor environmental quality can be improved.