In this paper, we discussed the Cu - Al2O3/H2O (Hybrid nanofluid) flow over permeable exponentially stretching channel. The hybrid nanofluid involves two kinds of nanoparticles along with base fluid (pure water). Our research objective is to evaluate the heat transfer rate of hybrid nanofluid.The resulting system is numerically tackled via shooting method (bvp4c).The hybrid nanofluid gains larger rate of heat transfer as compared to simple nanofluid. The impact of non-dimension parameter on temperature profile, boundary layer will be analyzed for enormous values of dimensionless parameter. Also, boundary layer thickness when γ 0 (suction) will be compared. The present results with the existence literature will be compared for justification/validation.