The effect of multiple slip boundary conditions is one more important physical parameter on the flow investigation and have been studied in this analysis. Further, the effect of Ohmic heating and varying chemical reaction on non-Newtonian Prandtl hybrid nanofluid with water based nanofluids to an extending of leading edge was also investigated to this current analysis. An inclined magnetic field is introduced to fluid flow to regulate the fluid stream. Hybrid nanomaterial is synthesized by the dispersion of Cu and Cofe2O4 nanoparticles in Prandtl fluid. All chemical science specifications of nanofluid are measured as constant. Due to the nanofluid particles motion, the fluid concentration is inspected underneath chemical implications. A mathematical model is developed by assuming the flow as incompressible and purely cartesian coordinate system and appropriate non-dimensional variables are introduced for problem simplifications and dimensional analysis. The scheme for semi analytical study named Homotopy Analysis Method (HAM) is implied to get solutions to the equations. The procedure is then displayed pictorially where fluid velocity, temperature and concertation against various pertinent parameters are examined. It was found that, the Concentration field profiles have been shown to deteriorate because molecule diffusivity reduces as the chemical reaction parameter rises in both cases. In order to maintain thermal balance management in tiny heat density equipment and gadgets, current research may also be helpful in enhancing the thermal efficiency of heat exchangers.