Abstract The development of innovative materials aiming to achieve energy savings is a main focus in the building technology sector. In this context, aerogel-enhanced products are often indicated as promising materials for increasing the thermal resistance of the building envelope. In particular, aerogel blankets have already started showing their effectiveness in retrofitting projects, while the development and adoption of aerogel-enhanced renders and aerogel-incorporating glazing systems is progressing. Based on the state of the art, this paper describes several new aerogel-enhanced systems that have been developed over the last few years at Ryerson University in Toronto, ON. In particular, the paper presents the recent results regarding aerogel-enhanced plasters, lightweight concretes, blankets, and glazing systems. Thermal characterization tests of these new materials confirm the superior performance for building retrofits. For example, the thermal conductivity of plasters with more than 80%vol. aerogel is below 0.025 W/(mK), a tenth of the respective value for traditional plasters, while mortars with more than 30%vol. aerogel show a thermal conductivity as low as 0.23 W/(mK). The newly presented aerogel-based systems are then assessed for the retrofitting project of an educational building located in Toronto. An extensive energy audit was conducted through measurements of the envelope thermal characteristics, the building airtightness, and several indoor environmental parameters. The audit helped to build an accurate energy model that was used for analyzing the energy consumptions of the building and assessing several energy saving measures. The study showed that high thermal resistance values could be obtained installing thin aerogel-enhanced products in the opaque and transparent envelope, with overall building energy savings up to 34%, with limited impacts and interruptions on the building functionality and internal usable space. However, the high costs of aerogel-enhanced products made their payback times of several decades and represented a barrier for the adoption of most of the systems presented in this paper.