Abstract In this paper, a novel ejector-based multi-evaporator refrigeration system using R134a is proposed to meet different working modes of refrigerated trucks running in tropical regions. The Computational Fluid Dynamics (CFD) simulation is implemented to research the performance of ejectors utilized in both air conditioning - refrigerating mode and air conditioning - freezing mode. Consequently, crucial ejector geometrical parameters such as area ratio (AR), nozzle exit position (NXP), lengths of primary nozzle and diffuser are optimized for each mode. Moreover, a novel approach by taking the deviation of the entrainment ratio or secondary mass flow rate over the deviation of the geometrical parameter into account to evaluate the ejector performance sensitivity to each geometrical parameter is first time presented to the best of the authors’ knowledge. The results show that: 1) Area ratio, NXP, lengths of primary nozzle and diffuser of the ejector in the air conditioning - freezing mode are almost twice as those in the air conditioning - refrigerating mode; 2) The performance of both ejectors is primarily influenced by area ratio and NXP; 3) The proposed sensitivity indicator can better evaluate the sensitivity of the ejector performance to geometrical parameters.