Abstract An energy hub is a multi-carrier energy system that is capable of coupling various energy networks. It increases the flexibility of energy management and creates opportunities to increase the efficiency and reliability of energy systems. When plug-in hybrid electric vehicles (PHEVs) are incorporated into the energy hub, batteries can act as an aggregated storage system, increasing the potential integration of variable renewable energy sources (RES) into power system networks. This paper presents a new model for the optimal operation of an energy hub that includes RES, PHEVs, fuel cell vehicles, a fuel cell, an electrolyzer, a hydrogen tank, a boiler, an inverter, a rectifier, and a heat storage system. A novel model is developed to estimate the uncertainty associated with the power consumption of PHEVs during trips using information gap decision theory (IGDT) under risk-averse and risk-seeking strategies. Simulation results demonstrate that the proposed method maximizes the objective function under the risk-neutral and risk-averse strategies, while minimizing the objective function under the risk-seeking strategy. Results from the modeling show that considering the uncertainty associated with the power consumption of PHEVs using IGDT enables the energy hub operator to make appropriate decisions when optimizing the operation of the energy hub against possible changes in power consumption of PHEVs.