Abstract Subcooled flow boiling is frequently encountered in hot assemblies in nuclear power plant. Considerable efforts have been made to improve the understanding of boiling process and prediction of critical heat flux (CHF). In this study, the effects of non-uniform heat input on heat transfer characteristics are further investigated, so that more realistic descriptions of practical systems can be achieved vis-a-vis usual heat input assumptions. A CFD model has been built to predict subcooled flow boiling process in a vertical round pipe. The capability of the model is validated against experimental results in the publication. A variety of non-uniform heat input profiles are tested using this validated CFD model. Results show that a regular triangle-shape heat input profile will cause stronger vapour generation in the middle of the heating region. Also, the risk of reaching CHF may be increased with the position of maximum heat flux moving downstream.