Anaerobic digestion of palm oil mill effluent (POME) and deoiled POME was investigated both in batch assays and continuous reactor experiments using up-flow anaerobic sludge blanket (UASB) and expanded granular sludge bed (EGSB) reactors. The methane potential determined from batch assays of POME and deoiled POME was 503 and 610 mL-CH(4)/gVS-added, respectively. For the treatment of POME in continuously fed reactors, both in UASB and EGSB reactors more than 90% COD removal could be obtained, at HRT of 5 days, corresponding to OLR of 5.8 gVS/(L-reactor.d). Similar methane yields of 436-438 mL-CH(4)/gVS-added were obtained for UASB and EGSB respectively. However, for treatment of deoiled POME, both UASB and EGSB reactors could operate at lower OLR of 2.6 gVS/(L-reactor.d), with the methane yield of 600 and 555 mL-CH(4)/gVS-added for UASB and EGSB, respectively. The higher methane yield achieved from the deoiled POME was attributed to lower portion of biofibers which are more recalcitrant compared the rest of organic matter in POME. The UASB reactor was found to be more stable than EGSB reactor under the same OLR, as could be seen from lower VFA concentration, especially propionic acid, compared to the EGSB reactor.