The European Commission aims to reduce the greenhouse gas emissions of the European Union's building stock by 60% by 2030 compared with 1990. Meanwhile, the global demand for cooling is projected to grow 3% yearly between 2020 and 2050. High-temperature cooling systems provide cooling with lower exergy use than conventional cooling systems and enable the integration of renewable energy sources, and can play a crucial role in meeting the growing cooling demand with less energy use. The aim of this study is to analyse and critically evaluate two high-temperature cooling systems in terms of their energy and exergy use in a case study. We also consider thermal comfort performance, CO2 emissions, and sensitivity to changing operating conditions. The two systems considered are a mechanical ventilation system with heat recovery combined with geothermal cooling (GeoMVHR) and a radiant cooling system with ceiling panels connected to the same geothermal cooling (GeoRadiant) system. The study is conducted using building energy models of a typical office building belonging to a three-building school complex located in Sant Cugat near Barcelona, Spain. IDA ICE 4.8 simulation software was used for the simulations. The results show that the two different installations can produce near-identical thermal comfort conditions for the occupants. The GeoRadiant system achieves this result with 72% lower electricity use and 60% less exergy destruction than the GeoMVHR system. Due to the higher electricity use, the CO2 emissions caused by the GeoMVHR system are 3.5 times the emissions caused by the GeoRadiant system. Datasets: "Building energy simulation data results" and "Acquired data from existing and/or new installed meters or from existing BEMS (pre intervention EcoSCADA monitoring data)" - Raw data is available upon request. Follow the link and fill the request form.