For the first time methanol tolerant Platinum Group Metal-free (PGM-free) Oxygen Reduction Reaction (ORR) electrocatalyst commercially available on market is integrated into the cathodic layer of highly performed Direct Methanol Fuel Cell (DMFC). The intrinsic ORR activity of Fe-N-C electrocatalyst is studied by Rotating Disk Electrode (RDE) technique with and with no methanol added, confirming material inactivity towards Methanol Oxidation Reaction (MOR). The electrocatalyst is tested in DMFC conditions where such important parameters as catalyst:ionomer ratio, concentration of methanol and operational temperature are varied and optimized for highest performance. The obtained activity and methanol tolerance in RDE measurements of commercial Fe-N-C catalyst is found to be comparable with previously reported state-of-the-art PGM-free cathodic materials. Furthermore, this material, used at the cathode compartment of a DMFC, allows reaching the highest power density recorded for PGM-free catalysts in a DMFC until now under similar conditions.