Solid titanium beryllide blocks will be used for neutron multiplication in the helium-cooled pebble bed (HCPB) blanket concept of EU DEMO. A combination of hot extrusion of Be-Ti powders and subsequent hot isostatic pressing (HIP) of the obtained Be-Ti composites has been proposed for manufacturing such blocks. This work is devoted to the study of the effect of HIP at 1000–1200 °C on the structure and properties of Be-Ti composites in order to optimize the HIP parameters. The HIP at 1000–1200 °C resulted in an almost single-phase titanium beryllide (TiBe$_{12}$) with small amounts of Be and other phases, which gradually dissolve with an increase in the HIP temperature. Such a treatment at 1000 and 1100 °C provides a very fine-grained microstructure of TiBe$_{12}$ with an average grain size of 0.3 and 0.6 μm, respectively. The resulting titanium beryllide is characterized by high microhardness of 1350–1480 HV$_{0.1}$ depending on the HIP temperature. According to the nanoindentation tests of the Be-Ti composite after HIP at 1100 °C, the indentation modulus of TiBe$_{12}$ can be estimated as 295 GPa. The fracture toughness of the TiBe$_{12}$ was determined as 1.5–1.7 MPa·m$^{1/2}$. The temperature of 1100 °C was chosen as optimal for the HIP of Be-Ti composites after hot extrusion. The titanium beryllide obtained in this way was used to manufacture a reduced size mockup of Ø20 mm × 18 mm. The mockup has no visible surface defects and can be used for further experiments.