Abstract Top-spray configurations are widely used in pharmaceutical fluidized beds for particle coating and granulation. The process is complex due to the change of particle moisture as well as particle density. It is important to investigate the flow hydrodynamics in the process. In this paper, electrical capacitance tomography (ECT) combined with pressure transducers are used to investigate the flow hydrodynamics of gas-solids flow in a top-spray fluidized bed for wetting and drying. The flow characteristics investigated include bubble size, dominant frequency and standard deviation. Discrete wavelet transforms (DWT) and Fast Fourier Transform (FFT) are used to analyze the capacitance and pressure signals. The effects of key process parameters, including superficial velocity, particle size and spraying conduction on the flow hydrodynamics, are analyzed. The result indicates that both the material moisture and particle size influence the minimum fluidized velocity and bubble characteristics during the wetting and drying process. The result also indicates that the moisture content of particles and superficial fluidization velocity are two main factors, which determine the bubble characteristics in the top-spray process. The bubble size presents a complex trend, which is influenced by the spray pressure. The fluctuation frequency of bubbles presents a different trend in the wetting and drying stage.