The aim of this work is to show the effects in a PV cell of the combined profiles of non-uniform temperature and radiation. Particular attention is paid to the modelling of cell operation at open circuit voltage with those profiles, as long as they serve as a general model in different circumstances: combined direct Gaussian temperature and radiation profiles, with several temperature amplitudes and movement of these profiles across the cell; analysis under Gaussian concentrated illumination and inverse Gaussian temperature profile simulating a general cell cooling device. In addition, we will study the cell behaviour under truncated radiation and temperature profiles. Irregular radiation and temperature distributions will also be studied.