Given the challenges faced by companies and society in general in terms of mitigating the effects of climate change and digitalisation, fostering and supporting digital and sustainable entrepreneurship represents a fundamental goal. Our research seeks to study the impact of national entrepreneurship systems (NESs) on what is known as the twin transition. Through recourse to dynamic panel econometric techniques applied to various databases (Eurostat, FAO, GEM, UN, and World Bank), we were able to evaluate the effect of the entrepreneurial attitudes, abilities and aspirations, and components of NESs, on the twin transition (digital and environmental). Globally, our results stand out for the positive interactions established by the entrepreneurial attitudes, abilities and aspirations, as pillars of NESs, with the digital and environmental transitions. Furthermore, the level of national economic development returns a positive moderating effect on the relationship between the NES components and the twin transitions.