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Toxicology Letters
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Toxicology Letters
Article . 2009 . Peer-reviewed
License: Elsevier TDM
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https://pubmed.ncbi.nlm.nih.go...
Article . 2009
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Toxicology Letters
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Drug interaction between ethanol and 3,4-methylenedioxymethamphetamine (“ecstasy”)

descriptionPublicationkeyboard_double_arrow_right Article , Journal 01 Jul 2009Publisher:Elsevier BVJournal:Toxicology Letters, volume 188, pages 167-172 (issn: 0378-4274, Copyright policy )
Authors: Natalie D. Eddington; Byoung-Joon Song; Insong J. Lee; Kwan-Hoon Moon; Vijay V. Upreti;

doi: 10.1016/j.toxlet.2009.03.023

pmid: 19446252

pmc: PMC3596109

Drug interaction between ethanol and 3,4-methylenedioxymethamphetamine (“ecstasy”)

Abstract

Alcohol (ethanol) and 3,4-methylenedioxymethamphetamine (MDMA, ecstasy) are frequently co-abused, but recent findings indicate a harmful drug interaction between these two agents. In our previous study, we showed that MDMA exposure inhibits the activity of the acetaldehyde (ACH) metabolizing enzyme, aldehyde dehydrogenase2 (ALDH2). Based on this finding, we hypothesized that the co-administration of MDMA and ethanol would reduce the metabolism of ACH and result in increased accumulation of ACH. Rats were treated with MDMA or vehicle and then administered a single dose of ethanol. Liver ALDH2 activity decreased by 35% in the MDMA-treated rats compared to control rats. The peak concentration and the area under the concentration versus time curve of plasma ACH were 31% and 59% higher, respectively, in the MDMA-ethanol group compared to the ethanol-only group. In addition, the MDMA-ethanol group had 80% higher plasma transaminase levels than the ethanol-only group, indicating greater hepatocellular damage. Our results not only support a drug interaction between MDMA and ethanol but a novel underlying mechanism for the interaction.

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Keywords

Male, Ethanol, Aldehyde Dehydrogenase, Mitochondrial, N-Methyl-3,4-methylenedioxyamphetamine, Retinal Dehydrogenase, Mitochondria, Liver, Acetaldehyde, Aldehyde Dehydrogenase, Aldehyde Dehydrogenase 1 Family, Rats, Isoenzymes, Mitochondrial Proteins, Rats, Sprague-Dawley, Animals, Drug Interactions, Chemical and Drug Induced Liver Injury

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    citations
    This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    		 23
    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
    		 Average
    influence
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    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
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citations
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
23
Average
Average
Top 10%
bronze
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