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Horse Liver Alcohol Dehydrogenase-Catalyzed Oxidative Lactamization of Amino Alcohols

descriptionPublicationkeyboard_double_arrow_right Article , Journal 07 Aug 2018 Denmark, Germany, Netherlands, Germany Publisher:American Chemical Society (ACS)Journal:ACS Catalysis, volume 8, pages 8,680-8,684 (issn: 2155-5435, eissn: 2155-5435, Copyright policy )
Authors: Lei Huang; Frank Hollmann; Selin Kara; Selin Kara; Giovanni V. Sayoga;

doi: 10.1021/acscatal.8b02355

handle: 11420/3054

Horse Liver Alcohol Dehydrogenase-Catalyzed Oxidative Lactamization of Amino Alcohols

Abstract

A direct synthesis of lactams (5-, 6-, and 7-membered) starting from amino-alcohols in a bienzymatic cascade is reported. Horse liver alcohol dehydrogenase together with the NADH oxidase from Streptococcus mutans were applied for the oxidative lactamization of various amino alcohols. Crucial parameters for the efficiency of this cascade reaction were elucidated. This report represents a direct approach for biocatalytic oxidative lactamization reaction.

Countries
Denmark, Germany, Netherlands, Germany
Related Organizations
Keywords

cofactor regeneration, oxidoreductases, horse liver alcohol dehydrogenase, enzymatic cascades, lactams

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citations
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
views
OpenAIRE UsageCountsViews provided by UsageCounts
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31
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7
4
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