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Cocaine- and amphetamine-regulated transcript in the nucleus accumbens shell attenuates context-induced reinstatement of alcohol seeking.

descriptionPublicationkeyboard_double_arrow_right Article , Journal 01 Oct 2012Publisher:American Psychological Association (APA)Journal:Behavioral Neuroscience, volume 126, pages 690-698 (issn: 0735-7044, eissn: 1939-0084,

Authors: E. Zayra Millan; Gavan P. McNally;

doi: 10.1037/a0029953

pmid: 23025832

Cocaine- and amphetamine-regulated transcript in the nucleus accumbens shell attenuates context-induced reinstatement of alcohol seeking.

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Abstract

We investigated the impact of cocaine- and amphetamine-regulated transcript (CART) in the nucleus accumbens shell (AcbSh) on context-induced reinstatement of alcoholic beer-seeking. Rats were trained to respond for 4% (vol/vol) alcoholic beer in one context (A) followed by extinction in a second context (B). Rats were subsequently tested for renewal of extinguished responding in the training context (A). Return to the training context elicited responding (reinstatement), whereas intra-AcbSh injections of CART (55-102) attenuated reinstatement without affecting general behavioral activity (Experiment 1). CART (55-102) attenuated reinstatement dose-dependently across the 0.025 - 2.5 μg range (Experiment 2), and no effect was observed with the inactive CART (1-27) fragment (Experiment 3). Together, these findings suggest that intra-AcbSh CART (55-102) modulates the impact of drug-associated environments on reward seeking behavior.

Related Organizations

UNSW Sydney
Australia

Keywords

Male, Behavior, Animal, Ethanol, Drug-Seeking Behavior, Beer, Nerve Tissue Proteins, Self Administration, Nucleus Accumbens, Peptide Fragments, Extinction, Psychological, Rats, Animals, Rats, Long-Evans

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