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Chronic alcohol remodels prefrontal neurons and disrupts NMDAR-mediated fear extinction encoding

descriptionPublicationkeyboard_double_arrow_right Article , Other literature type , Journal 02 Sep 2012 Switzerland Publisher:Springer Science and Business Media LLCJournal:Nature Neuroscience, volume 15, pages 1,359-1,361 (issn: 1097-6256, eissn: 1546-1726,

Copyright policy )Funded by:NIH | Role of the Dopaminergic ..., NIH | Chronic Alcohol Induced D..., NIH | The effect of alcohol dri... +1 projects

Authors: Kristen E. Pleil; Thomas L. Kash; Sophie Masneuf; Andrew Holmes; Lauren DeBrouse; Marguerite Camp; Giovanni Colacicco; +8 Authors

doi: 10.1038/nn.3204 , 10.17615/zxvy-9a25

pmid: 22941108

pmc: PMC3471649

Chronic alcohol remodels prefrontal neurons and disrupts NMDAR-mediated fear extinction encoding

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Abstract

Alcoholism is frequently co-morbid with posttraumatic stress disorder (PTSD) but it is unclear how alcohol impacts neural circuits mediating recovery from trauma. We found that chronic intermittent ethanol (CIE) impaired fear extinction and remodeled the dendritic arbor of medial prefrontal cortical (mPFC) neurons in mice. CIE impaired extinction encoding by infralimbic (IL) mPFC neurons in vivo, and functionally downregulated burst-mediating NMDA GluN1 receptors. These findings suggest alcohol may increase risk for trauma-related anxiety disorders by disrupting mPFC-mediated extinction of fear.

Country

Switzerland

Related Organizations

University of North Carolina at Chapel Hill
United States
National Institutes of Health
United States
National Institute On Alcohol Abuse and Alcoholism
United States
Uniformed Services University of the Health Sciences
United States
National Institute On Alcohol Abuse and Alcoholism
United States

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Keywords

Neurons, Ethanol, Action Potentials, Down-Regulation, Prefrontal Cortex, 610 Medicine & health, Dendrites, Fear, Receptors, N-Methyl-D-Aspartate, Article, Extinction, Psychological, Mice, 570 Life sciences; biology, Animals, Institute of Anatomy

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	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Top 10%
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Top 1%