In this paper, a comparative thermodynamic analysis on energy and exergy viewpoint is done on different low global warming potential (GWP) refrigerants to find the possible alternative of high GWP refrigerant R410A. R410A is used nowadays in air conditioning systems due to its ozone-friendly characteristic as zero ozone depletion potential (ODP=0) but it has high GWP (GWP=1924) that leads to global warming. Now a day’s global warming is considered to be one of the critical aspects when environmental protection is taken into consideration and researchers from every corner of the globe are working to find refrigerants that not only have zero ODP but it has low GWP too. In this analysis, four prospect refrigerants namely R32, R447A, R447B, and R452B have been studied to find their suitability to replace R410A on different performance criteria as the coefficient of performance (COP), power consumption, exergy efficiency, and exergy destruction. Thermodynamic properties of the studied refrigerants have been taken from the Genetron Properties 1.4 software. The result indicates that all the studied refrigerants have better performance characteristics compared to R410A but R447A has maximum COP and exergy efficiency along with the least total exergy destruction that makes it a possible alternate of R410A.