According to the fact that the traditional manual management method can not solve the problem of frequent accidents in the engineering construction process, the integrated scheme of safety prevention based on BIM and RFID is put forward, and the principle and technical feasibility of the integrated scheme are analyzed. Based on the integration technology scheme, the multi-layer architecture design pattern is adopted, and the software hierarchy of the integration system is designed in detail. On this basis, the integrated application network for engineering construction safety control is analyzed and designed by using the technology based on BIM and RFID. The research results of this paper provide a feasible technical reference scheme for the automatic identification and dynamic monitoring and early warning of the hidden dangers in the construction site.