Recent research studies have shown the advantages of using double-skin façade (DSF) and phase change material (PCM) in reducing the amount of building heat, especially for tropical and subtropical climates. Also, by adding photovoltaic (PV) cells in the facade of buildings, the solar heat of the building can be reduced and the electricity generated can lower the energy cost of the building. Since there is a strong interdependence among the energy performance of DSF, PV, and PCM as well as weather conditions, geography, and building orientation, in this paper, their simultaneous energy performance is studied under different climatic conditions of Iran. Also, all the cases are compared from an economic point of view. Based on the results obtained in this research, it can be concluded that the implementation of DSF and integration of PCM with it in the Mediterranean climate, the cold semi-arid climate, and the warm semi-arid climate of Iran is technically possible and offers the benefits of energy saving by changing the quality of spaces by using daylight as well as controlling the solar system, natural ventilation, sound insulation, and thermal insulation in winter and summer.