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Hampered long-term depression and thin spine loss in the nucleus accumbens of ethanol-dependent rats

descriptionPublicationkeyboard_double_arrow_right Article , Journal 13 Aug 2014 United States, Italy Publisher:Proceedings of the National Academy of SciencesJournal:Proceedings of the National Academy of Sciences, volume 111 (issn: 0027-8424, eissn: 1091-6490,

Authors: E. Sanna; E. Sanna; Valentina Licheri; Carla Cannizzaro; Giuseppe Talani; Marco Diana; Saturnino Spiga; +7 Authors

doi: 10.1073/pnas.1406768111

pmid: 25122682

pmc: PMC4156750

handle: 11584/226840

Hampered long-term depression and thin spine loss in the nucleus accumbens of ethanol-dependent rats

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Abstract

SignificanceThis paper examines the intimate neuroarchitecture of the nucleus accumbens shell region and how it affects synaptic plasticity in alcohol-dependent rats. To do so, a simultaneous morphometrical/immunofluorescence method was applied to visualize various types of dendritic spines and patch-clamp techniques to detect changes in synaptic currents. Using these tools, we show a selective loss of “long thin” spines accompanied by an impaired long-term depression (LTD) in alcohol-dependent rats. Dopaminergic and glutamatergic signaling are similarly altered. The results highlight the role of long thin dendritic spines in the genesis of LTD in alcohol dependence.

Countries

United States, Italy

Related Organizations

National Research Council
Italy
University of Palermo
Italy
Neuroscience Institute
Italy
National Academies of Sciences, Engineering, and Medicine
United States
University of Cagliari
Italy

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Keywords

Male, 571, Dendritic Spines, Biological Psychology, Wistar, Glutamic Acid, glutamate, Synaptic Transmission, Nucleus Accumbens, Substance Misuse, Alcohol Use and Health, Organ Culture Techniques, Behavioral and Social Science, Golgi, Psychology, Animals, Rats, Wistar, synaptic plasticity, Neuronal Plasticity, Biomedical and Clinical Sciences, Ethanol, Depression, Dopaminergic Neurons, Long-Term Synaptic Depression, Neurosciences, Central Nervous System Depressants, Pharmacology and Pharmaceutical Sciences, Brain Disorders, Dopamine; Glutamate; Golgi; Synaptic plasticity; Alcoholism; Animals; Central nervous system depressants; Dendritic spines; Dopaminergic neurons; Ethanol; Glutamic acid; Long-term synaptic depression; Male; Neuronal plasticity; Nucleus accumbens; Organ culture techniques; Rats; Rats, Wistar; Synaptic transmission; Multidisciplinary, Rats, Alcoholism, Mental Health, Good Health and Well Being, Mental health, dopamine

Impact byBIP!

	citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	88
	popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.	Top 10%
	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Top 10%
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Top 1%