Climate change policies are prepared in a power-loaded environment, where different policy actors interact to meet their personal or collective interests. This paper argues that the ‘power interplay’ between actors plays a significant role in shaping and re-shaping climate change policies. We present examples from South Asia (Nepal, India, Bangladesh, and Pakistan) to show how actors’ power interplay at the local, sub-national, national and transboundary levels influences climate change policy-making. We show that negative effects of power interplay are prominent in the climate policy domain of South Asia, including short-termism of local adaptation plans, exclusion of certain policy actors in the policy-making processes, lack of transboundary-level adaptation, and lack of coordination between actors. Nuances also exist, such as the state's authority in prioritizing technical solutions, exclusionary design and implementation of climate policies, and an agenda of securitization; these can further marginalize the actors involved in climate change policy processes. The negative effects of power interplay in South Asia can limit the success of on-the-ground implementation of adaptation and mitigation strategies, limit adaptive capacity among communities, and possibly counter the development of a strong climate change solutions space. Lastly, we argue that there are no silver bullet solutions to power asymmetries and appeal to policy actors – in South Asia and elsewhere – to design context-specific and power-sensitive policy-making approaches. Negative effects of power interplay have led to the exclusion of certain policy actors (especially communities at risk) in policy-making processes and a lack of transboundary-level adaptation in South Asia. Hard infrastructure-based adaptation measures tend to exacerbate the vulnerability of the communities at risk in South Asia. Policy actors must design context-specific and power-sensitive policy-making climate adaptation and mitigation approaches to reduce the negative impacts of power interplay.